Cell肥胖形成肿瘤微环境中的代谢以

PaperReading

01

ObesityShapesMetabolismintheTumorMicroenvironmenttoSuppressAnti-TumorImmunity

AlisonE.Ringelet.al

Cell,

DepartmentofCellBiology,BlavatnikInstitute,HarvardMedicalSchool

Obesityisamajorcancerriskfactorwhichinducessystemicperturbationsleadingtodyslipidemia,insulinresistance,alteredhormonelevels,andinflammation.However,ithasnotyetbeenreportedhowchangesinsystemicmetabolisminducedbyobesityaffectimmunecellsinthelocaltumormicroenvironment.Thus,inthispaper,theauthorsinvestigatedthatHFDcanacceleratetumorgrowth.FurtheranalysisshowedthatHFDespeciallyaffectedCD8+Tcellnumbersandfunctioninthetumor.Usingsinglecellsequenceanalysis,theyfoundthatlymphocytesweresignificantlyreducedinanimalsonHFDandnaiveorunstimulatedTcellstendedtobeenrichedwithHFDdisplayedalteredexpressionofmajorcentralcarbonmetabolicpathways.Usingmetabolic,proteomic,andgenomicapproaches,aswellasmultiplexedtissueimaging,theirdatarevealedMetabolicRemodelinginTumorswithHFDthatenhancedfattyaciduptakebytumorcellsleaveTcellsdeprivedoffattyacidsintheTME.Inaddition,theydemonstratedthatpreventingHFD-inducedmetabolicrewiringbymodulatingPHD3expressionintumorcellscouldcontrolfattyacidavailabilityintheTME,finallyaffectingCD8+TcellresponsesandtumorgrowthonHFD.Insummary,thispaperoffersapossibilitythatimplicationsfortherapeuticinterventionstargetingcancermetabolismmayhaveimpactsontheantitumor-immunityandprecisionmedicine.

转载请注明：http://www.gwoao.com/rcbj/32839.html